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  • Our Experts
  • Events & News
  • Research
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  • Affiliated Centers
    • Brehm Center for Diabetes Research
    • JDRF Center of Excellence at the University of Michigan
    • Michigan Center for Diabetes Translational Research (MCDTR)
    • Michigan Diabetes Research Center (MDRC)
      • About MDRC
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        • Clinical
        • Microscopy, Imaging and Cellular Physiology
        • Molecular Genetics
      • Pilot & Feasibility
      • MDRC Membership
    • Michigan Mouse Metabolic Phenotyping Center
    • Michigan Nutrition Obesity Research Center (MNORC)
    • Diabetes and Obesity Clinical Research Core
  • About
  • Brehm Center for Diabetes Research
  • JDRF Center of Excellence at the University of Michigan
  • Michigan Center for Diabetes Translational Research (MCDTR)
  • Michigan Diabetes Research Center (MDRC)
    • About MDRC
    • Cores
      • Administration
      • Animal Studies
      • Clinical
      • Microscopy, Imaging and Cellular Physiology
      • Molecular Genetics
    • Pilot & Feasibility
    • MDRC Membership
  • Michigan Mouse Metabolic Phenotyping Center
  • Michigan Nutrition Obesity Research Center (MNORC)
  • Diabetes and Obesity Clinical Research Core

Molecular Genetics

Michigan Diabetes Research Center (MDRC)

RRID: SCR_015119

Services

The Molecular Genetics Core provides services related to the application of genetic methodologies to research related to diabetes. 

Our services are currently run through MiCORES. MiCORES is an online core management system from Agilent Technologies and iLab Solutions designed to streamline the process of requesting and billing for core services.

Already a MiCORES user? Go to our core page, sign in using your umich credentials and navigate to the “request services” page.

Not yet a MiCORES user? To get started you must register for an account. Once you are registered, go to our core page, sign in using your umich credentials and navigate to the “request services” page.

Generation of targeted genetic rodent models, using CRISPR/Cas9 system in mouse or rat embryos:
  • Gene edited alleles
  • Knockout alleles
  • loxP-flanked alleles
  • Knock-in alleles (gene insertions, e.g., cre and Flp recombinases, rtTA (“TET-on”), GFP)
  • Cost includes design, construct assembly, embryo injection costs, and screening of potential founders.
  • Application of CRISPR-Cas9 technology in specific genetic backgrounds is available on request, at extra cost.
Generation of specialty viral vectors:
  • Constitutive or cre-inducible AAVs expressing transgenes of interest
  • Cost includes design and construct assembly. Viral production costs are paid directly to the Viral Vector Core by user. ALL costs may be waived for reagents likely to be of general interest, providing that PI is willing to allow distribution to other MDRC members following initial testing.
Specialty viral reagents:
  • Defective pseudotyped rabies viruses for tract-tracing, including AAV helper viruses
  • Under development: AAV-driven CRISPR/Cas9 reagents for gene ablation in animals

Cost of Services

Rates Effective 10/1/2020 - 10/1/2021

* non-UM customers please contact David Olson for quote

Rates with Transgenic Costs Built In (* U-M Customers)

Knock-In Rate

$10,242 per test

 

Knock-Out/Edit Rate

$8,882 per test

 

Flox Rate

$10,858 per test

Rates without Transgenic Costs

Knock-In Rate

$4,982 per test

 

Knock-Out/Edit Rate

$4,582 per test

 

Flox Rate

$4,345 per test

 

Plasmid Synthesis

$3,013 per test

 

ES Cell Plate Screening

$1,011 per test

 

Lab Tech Services

$32 per hour

Downloads

File
Service Agreement for External Customers*.pdf

* External Customers, please download, complete, and return the signed Service Agreement, along with the Service Request form and return to David Olson.

 

David P. Olson, MD, PhD

Brehm Tower Room 6442

 734-647-9538

Remember to cite the Michigan Diabetes Research Center (MDRC) in publications as follows:
“The project described was supported by Grant Number P30DK020572 (MDRC) from the National Institute of Diabetes and Digestive and Kidney Diseases”

Remember to cite the Michigan Diabetes Research Center (MDRC) in publications as follows:
“The project described was supported by Grant Number P30DK020572 (MDRC) from the National Institute of Diabetes and Digestive and Kidney Diseases”

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