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    • Brehm Center
    • JDRF Center of Excellence at the University of Michigan
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      • About Us
      • Core Services
        • Administrative Core
        • Nutrition, Exercise and Phenotype Testing Core
        • Childhood Obesity Research Core
        • Molecular Phenotyping
        • Adipose Tissue
        • Weight Management Program
        • Previously Supported Cores
      • Enrichment Programs
      • Pilot/Feasibility Grants
      • NORC Central
      • MNORC Membership
      • Debate: Weight Loss Independent vs Dependent Effects of Bariatric Surgery
    • Diabetes and Obesity Clinical Research Core
  • About
  • Brehm Center
  • JDRF Center of Excellence at the University of Michigan
  • Michigan Center for Diabetes Translational Research (MCDTR)
  • Michigan Diabetes Research Center (MDRC)
  • Michigan Mouse Metabolic Phenotyping Center - Live
  • Michigan Nutrition Obesity Research Center (MNORC)
    • About Us
    • Core Services
      • Administrative Core
      • Nutrition, Exercise and Phenotype Testing Core
      • Childhood Obesity Research Core
      • Molecular Phenotyping
      • Adipose Tissue
      • Weight Management Program
      • Previously Supported Cores
    • Enrichment Programs
    • Pilot/Feasibility Grants
    • NORC Central
    • MNORC Membership
    • Debate: Weight Loss Independent vs Dependent Effects of Bariatric Surgery
  • Diabetes and Obesity Clinical Research Core

Adipose Tissue

Michigan Nutrition Obesity Research Center (MNORC)

The University of Michigan  Adipose Tissue Core gathers experts from different laboratories across campus researching diabetes, obesity, and adipocyte biology.

Adipose Tissue Core Presentation

This joint laboratory core offers a large panel of experts of in vitro and in vivo adipose biology experiments. Our core can provide council on cell culture, differentiation, transfection and infection with virus, protein and RNA purification, lipolysis, Seahorse assays, glucose uptake assays, and tissue and cellular stains including Oil Red-O, Nile Red, Geimsa, and H&E stainings. Our group also offers expertise in animal experiments including glucose tolerance tests, insulin tolerance tests, tissue collection, drug injection, and many others.

Our services include:

  • Consultation services on your current research, such as providing guidelines on general strategies or technical aspects, suggesting new paths of research, reviewing specific aims based on our experience in the field of adipocyte function and regulation.
  • Protocols and reagents we have gathered related to the study of adipocytes can be shared upon request, demonstrated in our laboratory, or performed as a service.
  • Up to date lists of material are available for our customers: primers for qRT-PCR analysis of adipose genes, antibody references, various plasmids, viral vectors, mesenchymal precursors cells (including UCP-1), as well as transgenic and knock-out mice.
  • Samples have been processed for protein and RNA analysis and are available upon request from the database of tissues collected from mice fed with normal chow or high fat diet chow established by our core
  • Work with a panel of transgenic mice, which are available to address your specific questions if your study could benefit from the in vivo experiments.
  • Expertise in explant culture, more specifically ear mesenchymal stem cell culturing.
  • Generation of cell models from our transgenic animals can be provide upon request.
  • An RNA-sequencing database is being generated and will be available shortly. 

In addition, the core provides the infrastructure, expertise and training for in vitro studies of cellular and mitochondrial metabolism via a Seahorse XF Analyzer.

Seahorse XF Analyzer

The Seahorse XF instrument is used to assess extracellular O2, pH, glucose and lactate fluxes to provide estimates of glucose utilization in cells and tissues.

Contact

Please contact Hiro Mori morimori@umich.edu(link sends e-mail) and Sandie Wankel wankel@umich.edu(link sends e-mail) to schedule these services.

Research Facilities

Located at the North Campus Research Complex (NCRC), the MacDougald Laboratory includes equipment to perform experiments and analysis with cutting edge technologies. Besides the level 2 bench lab, a room is dedicated to cell culture and another to radioactivity labeling. The animal facility is also present in the building for breeding or mouse manipulation.

Directors

Ormond MacDougald, PhD
Director, Adipose Tissue Core
734-647-4880
macdouga@umich.edu

 

Carey Lumeng

Carey Lumeng, MD, PhD
Associate Director, Adipose Tissue Core
734-615-6242
clumeng@umich.edu

Research Acknowledgement

It is extremely important that our grant is cited in all publications resulting from the use of MNORC services. Our productivity and effectiveness as a center are measured in part by the citation of the grant in published work. Please use the following acknowledgement in your publications:

This work utilized Core Services supported by grant DK089503 of NIH to the University of Michigan.

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