Funding Opportunities

Purpose

Diabetes, along with its spectrum of related and comorbid diseases, represents one of the most prevalent and devastating health problems in Michigan, across the US, and worldwide. The University of Michigan (UM) possesses an array of resources (including strong clinicians, world-leading basic research, and a small but strong clinical research footprint) with which to address the challenges posed by diabetes and related disorders. Addressing these challenges requires planning and coordination among the many existing UM diabetes-related programs, however. The Caswell Diabetes Institute serves to coordinate among and support the various diabetes-related programs across Michigan Medicine.

Developing and supporting infrastructure and otherwise facilitating clinical research related to diabetes represents a major focus for the Caswell Diabetes Institute, along with its partner centers: the Michigan Diabetes Research Center (MDRC), the Michigan Center for Diabetes Translational Research (MCDTR), and the Michigan Nutrition and Obesity Research Center (MNORC). The Caswell Diabetes Institute Clinical/Translational Research Scholars Program seeks to identify and support the most promising early-stage scholars focused on clinical research relevant to diabetes. The Caswell Diabetes Institute Clinical/Translational Research Scholars Program will provide up to 50% salary support for up to 3 years, protecting this time from clinical care duties to allow successful clinical research scholarly activities. The Caswell Diabetes Institute Clinical Research Scholars Program will also provide strong mentoring regarding research and career advancement.

Eligibility

UM-based early-career faculty members seeking to establish a career in clinical/translational research relevant to diabetes (including obesity, metabolism and the complications of diabetes). The candidate and the department/division must commit to protecting at least 50% of the awardee’s time toward scholarly activities relevant to clinical/translational research, requiring that any clinical care commitment be less than 50%. A letter of commitment/support from the applicant’s department chair (or division chief, as appropriate) must affirm this commitment to protecting time for scholarly activities.

Applicants should have at least a main clinical/translational research mentor and defined support (or a path toward support) for a clinical/translation research project or projects relevant to diabetes. The applicant and mentor must also clearly define how this award would lead to an independent career in diabetes-related clinical/translational research for the awardee.

Proposals

Applications Due January 31, 2025

Applications will be reviewed by the Caswell Diabetes Institute Committee on Clinical Research, Mentoring and Development.

Decisions communicated by April 1 for July 1 funding.

Awards support 50% of the salary of selected individuals for three years. We envision supporting one new scholar each year.

Awardees are required to submit brief annual reports detailing their career and research progress, including information regarding their publications and/or grant funding.

APPLY

We encourage all early career faculty candidates from across the entire spectrum of diabetes and obesity with interest in joining our thriving group of physician scientists and capitalizing on the wealth of resources and expertise at University of Michigan to apply for the Caswell Diabetes Institute CTRSP program.

All early-career faculty members seeking to establish a career in clinical/translational research relevant to diabetes (including obesity, metabolism, and the complications of diabetes) are eligible and encouraged to apply. The candidate and the department/division they will join must commit to protecting at least 50% of the awardee’s time toward scholarly activities relevant to clinical/translational research, requiring that any clinical care commitment be less than 50%.

Potential candidates should send a letter of intent and CV, which include the following components:

1)   Candidate’s skills and qualifications that demonstrate track record and commitment to academic career in clinical research

2)   Candidate’s area(s) of interest in clinical research pertinent to Diabetes and Metabolic Diseases

Interested applicants or for more information regarding the Caswell Diabetes Institute Clinical Translational Research Scholars Program (CTRSP), please contact UM-CDI-CTRSP@umich.edu.

Kara Mizokami-Stout, MD

Dr. Mizokami-Stout was selected as the 2020 Clinical Translational Research Scholars Program awardee for her project "Continuous Glucose Monitoring and Type 2 Diabetes: Utilization, Outcomes, Triumphs and Challenges."

Yu Kuei (Alex) Lin, MD

Dr. Lin was selected as the 2021 Clinical Translational Research Scholars Program awardee for his project "A Personalized Mobile Health Program for Improving Hypoglycemia Management in Adults with Type 1 Diabetes"

David Flood, MD, MSc

Dr. Flood was selected as the 2022 Clinical Translational Research Scholars Program awardee for his project "Strengthening Global Diabetes Care through Implementation and Health Systems Research"

David T. Broome, MD

Dr. Broome was selected as the 2023 Clinical Translational Research Scholars Program awardee for his project “Proof of Concept: Mechanism of Action and Efficacy of Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) in HNF4A-MODY.”

Nate Haas, MD

Dr. Haas was selected as the 2024 Clinical Translational Research Scholars Program awardee for his project "Assessment of Continuous Glucose Monitor-Guided Management In DKA (ACID)"

Lindsay Ellsworth, MD

Dr. Ellsworth was selected as one of the first CTRSP scholars for her project "Impact of mother’s own milk compared to donor human milk on preterm infant metabolomics, growth, and metabolism."

Brian Schmidt, DPM

Dr. Schmidt was selected as one of the first CTRSP scholars for his project "Probiotic Diabetic Foot Ulcer (Pro-DFU) Healing."

The Fernandez Buddin Family Foundation Fellowship will support a fellow to continue advancing towards a cure for Type 1 Diabetes (T1D).

"We established the Fernandez Buddin Family Fellowship Fund at the University of Michigan to support type 1 diabetes research. Our oldest son was diagnosed with type 1 diabetes a few weeks before his 13th birthday. Being a T1D family we are motivated to help scientists find a cure for type 1 diabetes and we were led to the University of Michigan because of their renowned multi-disciplinary scientific research and commitment to diabetes research."

PURPOSE
The Fernandez Buddin Type 1 Diabetes Fellowship Grant Program (FBT1D) is sponsored by a generous gift to the Caswell Diabetes Institute (CDI) which created an endowment to support a promising research fellow in pursuit of improving our understanding of the causes of Type 1 Diabetes (T1D) and developing new cures. The goal of the program is to support promising fellows as they seek to develop a future independent career in T1D research.

Grant proposals can be anywhere in the spectrum of basic biomedical, clinical, or translational research, focused on key questions regarding the pathogenesis, diagnosis, prevention, or treatment of T1D. Specifically, the proposal is an “Idea” grant, focused on development of a novel approach, model, therapy, or reagent that could be mechanistically or therapeutically linked to ongoing and future research in T1D. Preliminary data is not required in support of the application.

ELIGIBILITY
Individuals currently serving in a post-doctoral or clinical fellowship capacity at the University of Michigan are eligible to apply in collaboration with their research/clinical mentor. These fellows should hold an MD, PhD, DVM, DPM, or other comparable degree. While applicants currently supported by other fellowship support programs (T, F, institutional fellowship or training awards) are eligible to apply, those with later-stage grants to aid the transition to independence (K grants, career development awards, etc.) are not eligible. Only one trainee may apply per research/clinical faculty mentor each year.

PROPOSALS
The proposals should be for one year of support, with requested funding up to $12,000. The CDI FBT1D Committee will review and rank the applications based on scientific merit and relevancy to T1D research. We anticipate funding one award, with funding to begin January 1, 2025.

The FBT1D awardee will be queried annually by CDI administrative staff and is required to provide information on the progress, publications, and funding that stem from the fellowship grant, as well as future funding and other career progress. The fellowship awardee is also expected to present their research at the annual CDI Metabolism, Obesity, Nutrition and Diabetes research symposium.

APPLY

Wenzhen Zhu, Ph.D.

Dr. Zhu's grant application entitled "Investigating the role of transthyretin in glucagon production and islet function" was selected for funding for 2023.

Russell Urie, Ph.D.

Dr. Urie's grant application entitled "Integrated Transcriptomic-Metabolomic Map of Type 1 Diabetes Initiation at a Surrogate Tissue Implant" was selected for funding for 2024.