My research is focused on identification of cellular and molecular mechanisms of glomerular disease initiation and progression. My lab interrogates kidney and other organ tissue from patients with early stage kidney disease to characterize the disease-relevant perturbations of molecular regulatory networks. We use highly granular interrogation methods and system biology approach to discover candidate mechanisms and target for interventions. In addition, we validate and further investigate these discoveries in tissues culture and rodent model systems of kidney disease and injury. Determining the role of Transforming Growth Factor-beta (TGF-beta) signaling network as well as long and short non-coding RNAs on these regulatory networks is a particular focus. Furthermore, I am leading several observational cohorts and biobanks, including C-PROBE and PRECISE, and are participate in several other studies and consortia, including NEPTUNE, the Human Cell Atlas and Kidney Precision Medicine Project (KPMP).